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MYP_109939
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Basic Information
T20v7(T20 [H6W; S7K; L8,24V; I9L; E10N; E11D; S12A; Q13R; N14E; K18N; E20Q; Q21E; L26I])
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
36 amino acids
C205H300N52O61
Standard
Sequence
YTSLIWKVLNDAREQQENNQETLVEIDKWASLWNWF
Physicochemical Analysis
4468.89 Da
4.36
-3.23
-3.44
-0.0897
-0.74
0.57
-0.04
30.25
86.67
0.1667
23490.00
23490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1885.50
-13.94
64.0
58.0
146.0
318.0
10.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0247131 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 JRCSF | U87 cells
0.16 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperOptimization of peptidic HIV-1 fusion inhibitor T20 by phage display. | Chen G, Cook JD, Ye W, Lee JE, Sidhu SS. | Protein Sci. 2019 Aug;28(8):1501-1512. | DOI:10.1002/pro.3669 | PMID:31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0285057 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 92HT021 | U87 cells
0.07 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperOptimization of peptidic HIV-1 fusion inhibitor T20 by phage display. | Chen G, Cook JD, Ye W, Lee JE, Sidhu SS. | Protein Sci. 2019 Aug;28(8):1501-1512. | DOI:10.1002/pro.3669 | PMID:31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0291606 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 JRCSF:inhibition of virus infection in U87 cells
0.16 μg/mL
IC50
PaperPubMed PMID: 31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0305383 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 JRCSF-GIA:inhibition of pseudovirus infection in U87 cells
5.1 μg/mL
IC50
PaperPubMed PMID: 31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0324656 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3
PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
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