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MYP_109866
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Basic Information
Emericellipsin A
Anticancer
Antimicrobial
Antimicrobial ▸ Antifungal
Standard
9 amino acids
C35H60N10O12
Standard
Sequence
PQAAIVASG
Physicochemical Analysis
812.91 Da
5.96
-0.04
-0.10
-0.0046
0.87
0.02
0.43
20.86
108.89
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
345.45
-4.65
12.0
12.0
24.0
57.0
1.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0343076 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
EmiA also has cytotoxic properties towards a wide range of tumor cell lines of various origins: HCT-116
2.3 μM
IC50
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0352921 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Klebsiella pneumoniae
25 μg/mL
MBC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0362212 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Pseudomonas aeruginosa ATCC 27853
>300 μg/mL
MIC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0369790 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
B16
16 μM
IC50
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0416729 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
C. tropicalis 156 or 1402
1-2 μg/mL
MIC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
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