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MYP_109866
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Basic Information
Emericellipsin A
Anticancer
Antimicrobial
Antimicrobial ▸ Antifungal
Standard
9 amino acids
C35H60N10O12
Standard
Sequence
PQAAIVASG
Physicochemical Analysis
812.91 Da
5.96
-0.04
-0.10
-0.0046
0.87
0.02
0.43
20.86
108.89
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
345.45
-4.65
12.0
12.0
24.0
57.0
1.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0290381 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Microdilution assays: The MIC values for EmiA were in the 0.5 ? ug/mL range: A. niger ATCC 16404
4 μg/mL
MIC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0309033 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
4 strains Staphylococcus aureus
12.5-25 μg/mL
MBC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0325646 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Escherichia coli MG1655
>300 μg/mL
MIC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0327051 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
A. terreus 3 K
0.5 μg/mL
MIC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0332065 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
A. fumigatus 390 m
2 μg/mL
MIC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
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