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MYP_109866
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Basic Information
Emericellipsin A
Anticancer
Antimicrobial
Antimicrobial ▸ Antifungal
Standard
9 amino acids
C35H60N10O12
Standard
Sequence
PQAAIVASG
Physicochemical Analysis
812.91 Da
5.96
-0.04
-0.10
-0.0046
0.87
0.02
0.43
20.86
108.89
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
345.45
-4.65
12.0
12.0
24.0
57.0
1.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0107726 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
5 strains E. faecium
25-50 μg/mL
MBC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0117448 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Since EmiA is more active, its activity was tested using additional multidrug-resistant fungal strains: Candida albicans 1402 or 1582 or ATCC 14053
2 μg/mL
MIC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0160386 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Bacillus cereus ATCC 14893
16 μg/mL
MIC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0175189 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
HPF
11.5 μM
IC50
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
RECORD: Rec_0204927 VERIFIED: YES
Provenance & Taxonomy
Emericellopsis alkaline [Fungus]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
the amino acid sequence has been extensively modified. Structure is Methyldecanoyl-MePro-AHMOD-Ala-Aib-Ile-Iva-bAla-Alaol-Glyol (see below). Chemical modification: P1 is methylated, residue 2 is represented by Q but it is 2-Amino-4-methyl-6-hydroxy-8-oxo decanoic acid (AHMOD), residue 4 is a methylated Ala (Aib), residue 6 is isovaline, residue 7 is beta-alanine, residue 8 is alaninol, and residue 9 is ethanolamine
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
A. niger 1133 m or 219
4 μg/mL
MIC
PaperA Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina.
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