Peptide Database

Peptide NameSLAY-screened peptide P5245

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC98H152N22O25S2

DescriptionStandard

        VPACLLIPSFLLCSFSPGHT
    

Molecular Weight2102.52 Da

Isoelectric Point (pI)6.70

Net Charge (pH 7.0)-0.20

Net Charge (pH 7.4) -0.49

Charge Density (pH 7.0) -0.0099

GRAVY Index1.24

Hydrophobic Moment 0.24

Boman Index0.51

Instability Index86.75

Aliphatic Index 117.00

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 699.45

LogP -4.67

H-bond Donors 25.0

H-bond Acceptors 28.0

Rotatable Bonds 59.0

Heavy Atoms 147.0

Ring Count 6.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0062150 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/