Peptide Database

Peptide NameP10

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC152H231N33O46S

DescriptionStandard

        SALEEQYKTFLDKFMHELEDLLYQLAL
    

Molecular Weight3288.72 Da

Isoelectric Point (pI)4.35

Net Charge (pH 7.0)-4.44

Net Charge (pH 7.4) -4.71

Charge Density (pH 7.0) -0.1646

GRAVY Index-0.20

Hydrophobic Moment 0.63

Boman Index0.08

Instability Index55.82

Aliphatic Index 108.52

Aromaticity 0.1481

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1291.54

LogP -5.96

H-bond Donors 43.0

H-bond Acceptors 44.0

Rotatable Bonds 112.0

Heavy Atoms 232.0

Ring Count 5.0

Amide Bonds 28.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0324935 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2 Cytotoxic

TargetThe peptide proved to be devoid of cell toxicity on Vero-E6 and Calu-3 cells

RECORD: Rec_0386142 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Replication inhibition

TargetSARS-CoV-2 | Vero-E6 cells

Activity10 μM

Method% inhibition

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperHuman ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. | Karoyan P, Vieillard V, Gómez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O. | Commun Biol. 2021 Feb 12;4(1):197. | DOI:10.1038/s42003-021-01736-8 | PMID:33580154 PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/

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