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MYP_109741
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Neurological / Signaling ▸ Tachykinin peptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Therapeutic angiogenesis
Standard
11 amino acids
C63H97N17O14S
Standard
Sequence
RPKPQQFFGLM
Physicochemical Analysis
1348.61 Da
11.00
1.76
1.55
0.1599
-0.70
0.24
-0.08
47.91
35.45
0.1818
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
510.84
-2.90
16.0
17.0
42.0
95.0
4.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0203483 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Substance P
9796
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Neuropeptide Neuromodulator Vasoactive Vasodilator Receptor modulation
Experimental: 2.1 (t1/2 of hydrolysis) minutes; /126 seconds; Mammalian: 1 hour; Yeast: 2 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Substance P (Equus caballus): PMID 7529108 PMID7529108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529108/
RECORD: Rec_0210994 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
PMID12074933 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12074933/
RECORD: Rec_0240571 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Substance P
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Vasoactive Vasodilator Receptor modulation
Experimental: 2.1 (t1/2 of hydrolysis) minutes; /126 seconds; Mammalian: 1 hour; Yeast: 2 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Substance P (Bos taurus): PMID 7529108 PMID7529108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529108/
RECORD: Rec_0246981 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0252001 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Substance P
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Neurotransmitter
HPLC and LC/ITMS
Bacterial strain B-9 cell culture, in vitro; 600 s
PMID22186872 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22186872/
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