Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2574H4015N645O745S17

DescriptionStandard

        MRTKAVQVLWGCFFLSDLYISSAQTVYPGIKARVTQRALDYGVLAGREMIEQMVKEKNIPDLEGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEIKSPLFEDTGRADLFLSGVYFTGIVVLARNDFGHPILKLQRCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIITSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYMELNLKGVFYPLDKLTDPPFLPVPFALPERHDSMLYVGISEFFFKSASFAYFTSGAFNVTLSMKEISSHLVQNSQGLGNVLSRIAEIYILSQPFMVRVMATEPPVISLQPDNFTLDIPASMVLLAQTENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESNRSNIEVLRFENILSSILHFGILPLANAKLQQGIPLPNPHKISFVNSDIEVFEGFLLISTDLKYETSLKQQLSFHGWEGLNLVSGQWRGKPVA
    

Molecular Weight56461.39 Da

Isoelectric Point (pI)5.25

Net Charge (pH 7.0)-12.68

Net Charge (pH 7.4) -13.53

Charge Density (pH 7.0) -0.0250

GRAVY Index0.16

Hydrophobic Moment 0.68

Boman Index0.16

Instability Index35.42

Aliphatic Index 103.81

Aromaticity 0.1026

Extinction Coeff. Reduced 45840.00

Extinction Coeff. Oxidized 46090.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0085154 VERIFIED: NO

Provenance & Taxonomy

OrganismOdobenus rosmarus divergens [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence