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MYP_109726
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Basic Information
Alloferon (3-13)
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
11 amino acids
C44H66N18O14
Standard
Sequence
VSGHGQHGVHG
Physicochemical Analysis
1071.11 Da
7.00
-0.00
-0.37
-0.0004
-0.65
0.26
0.17
-19.19
52.73
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
503.68
-7.76
17.0
17.0
33.0
76.0
3.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0354906 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Coxsackievirus 971 PT B2; HEp-2 cells
250 μM
IC50 (virus replication inhibition)
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0376675 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Non-cytotoxic
Vero cells
>=165 μM
Cytotoxicity assay (no cytotoxicity observed)
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0415659 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Human herpesvirus 1 clinical strain; HEp-2 cells
117 μM
IC50 (virus replication inhibition)
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0417058 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Entry inhibition
Coxsackievirus 971 PT B2; LLC-MK2 cells
93 μM
IC50 (virus replication inhibition)
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperNew alloferon analogues: synthesis and antiviral properties. | Kuczer M, Majewska A, Zahorska R. | Chem Biol Drug Des. 2013 Feb;81(2):302-9. | DOI:10.1111/cbdd.12020 | PMID:22883213 PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
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