Peptide Database

Peptide NameBig gastrin

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC178H262N46O55S2

DescriptionStandard

        QLGPQGPQHFIADLSKKQRPPMEEEEEAYGWMDF
    

Molecular Weight3990.39 Da

Isoelectric Point (pI)4.49

Net Charge (pH 7.0)-4.14

Net Charge (pH 7.4) -4.41

Charge Density (pH 7.0) -0.1217

GRAVY Index-1.16

Hydrophobic Moment 0.43

Boman Index-0.11

Instability Index75.79

Aliphatic Index 40.29

Aromaticity 0.1176

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1620.79

LogP -13.03

H-bond Donors 51.0

H-bond Acceptors 54.0

Rotatable Bonds 129.0

Heavy Atoms 281.0

Ring Count 10.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0120019 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyGastrin/cholecystokinin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

C-TermAmidation

Other ModsGln18 Pyroglutamylation; Tyr29 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide

RECORD: Rec_0303388 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 23.5%, E 0.0%, T 38.2%, C 38.2% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cell-Cell Communication

RECORD: Rec_0394322 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyBig gastrin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods29:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Myotropic Receptor modulation

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour