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MYP_109559
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C74H130N18O15
Standard
Sequence
ALWKTLLKKVLKA
Physicochemical Analysis
1511.94 Da
10.48
3.79
3.60
0.2917
0.45
0.66
0.10
7.85
157.69
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
552.62
-0.28
20.0
19.0
53.0
107.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0124108 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
TME-Suc-P
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Trimethylethylamino-succinyl
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum W2 (ring stage)
10 μM
Percent inhibition; [3H] Hypoxanthine incorporation assay
PaperIn vitro antiplasmodium effects of dermaseptin S4 derivatives PMID11897590 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11897590/
RECORD: Rec_0127066 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli U16318
9-3 μM
MIC
PaperPubMed PMID: 16407175 | PubMed PMID: 15917541 PMID16407175;15917541 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16407175/
RECORD: Rec_0129732 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
SC3-P
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Propionylation
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum W2 (ring stage)
10 μM
Percent inhibition; [3H] Hypoxanthine incorporation assay
PaperIn vitro antiplasmodium effects of dermaseptin S4 derivatives PMID11897590 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11897590/
RECORD: Rec_0131059 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
C8-P
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Octanoyl
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum W2 (ring stage)
10 μM
Percent inhibition; [3H] Hypoxanthine incorporation assay
PaperIn vitro antiplasmodium effects of dermaseptin S4 derivatives PMID11897590 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11897590/
RECORD: Rec_0133842 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum (ring stage)
7.7±0.9 μM
IC50; [3H] Hypoxanthine incorporation assay
PMID11937508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11937508/
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