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MYP_109559
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C74H130N18O15
Standard
Sequence
ALWKTLLKKVLKA
Physicochemical Analysis
1511.94 Da
10.48
3.79
3.60
0.2917
0.45
0.66
0.10
7.85
157.69
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
552.62
-0.28
20.0
19.0
53.0
107.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0063008 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Leishmania major
9
LC50
PMID11847217;11937508;16436701;15917541;21741801;16870756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11847217/
RECORD: Rec_0063164 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
H 2 N-CH 2 -CO-P
Amidation
Bio-Activity Profile
Antiparasitic
Human erythrocytes
10 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/11937508/ PMID11937508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11937508/
RECORD: Rec_0063702 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Lysyl-P
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Glycyl
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum (ring stage)
10 μM
Percent inhibition; [3H] Hypoxanthine incorporation assay
PMID11937508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11937508/
RECORD: Rec_0065233 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 61.5%, C 38.5% [Linear]
canonical L-amino-acid peptide [L]
Butylsulfonyl
Amidation
Bio-Activity Profile
Antiparasitic Antimicrobial Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0067953 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Isobutyryl-P
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Isobutyrylation
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum W2 (ring stage)
3.82±0.47 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperIn vitro antiplasmodium effects of dermaseptin S4 derivatives PMID11897590 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11897590/
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