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MYP_109559
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C74H130N18O15
Standard
Sequence
ALWKTLLKKVLKA
Physicochemical Analysis
1511.94 Da
10.48
3.79
3.60
0.2917
0.45
0.66
0.10
7.85
157.69
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
552.62
-0.28
20.0
19.0
53.0
107.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0289720 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
100 μM
Hemolysis
PMID11847217;11937508;16436701;15917541;21741801;16870756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11847217/
RECORD: Rec_0291817 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 61.5%, C 38.5% [Linear]
canonical L-amino-acid peptide [L]
Mercaptopropionyl
Amidation
Bio-Activity Profile
Antiparasitic Antimicrobial Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0296572 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Leishmania major
PMID11847217;11937508;16436701;15917541;21741801;16870756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11847217/
RECORD: Rec_0298181 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum
>10 μM
Percent inhibition; [3H] Hypoxanthine incorporation assay
PaperAntimalarial activities of dermaseptin S4 derivatives PMID10952593 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10952593/
RECORD: Rec_0298455 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
10 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/11897590/ PMID11897590 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11897590/
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