Peptide Database

Peptide NameHYL-4 (Derived from HYL)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC81H149N23O19S2

DescriptionStandard

        GIMSSLMKKLKKHIAK
    

Molecular Weight1813.32 Da

Isoelectric Point (pI)10.60

Net Charge (pH 7.0)4.84

Net Charge (pH 7.4) 4.58

Charge Density (pH 7.0) 0.3026

GRAVY Index-0.16

Hydrophobic Moment 0.66

Boman Index-0.06

Instability Index60.42

Aliphatic Index 103.75

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 699.06

LogP -4.39

H-bond Donors 25.0

H-bond Acceptors 27.0

Rotatable Bonds 69.0

Heavy Atoms 125.0

Ring Count 1.0

Amide Bonds 15.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0132288 VERIFIED: YES

Provenance & Taxonomy

OrganismHylaeus signatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans

Activity12 μM

MethodMIC

RECORD: Rec_0167809 VERIFIED: YES

Provenance & Taxonomy

OrganismHylaeus signatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus epidermidis

Activity10 μM

MethodMIC

RECORD: Rec_0209393 VERIFIED: YES

Provenance & Taxonomy

OrganismHylaeus signatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus 6271

Activity100 μM

MethodMIC

RECORD: Rec_0221484 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStaphylococcus epidermidis

Activity10 μM

MethodMIC

PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. PMID: 26998557. PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/

RECORD: Rec_0236493 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

Targethuman red blood cells

Activity400 μM

MethodLC50

PaperAntimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129. PMID: 26998557. PMID26998557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26998557/

FIRST PREV 1 2 3 NEXT LAST

Showing 5 records on this page Ã‚Â· Page 2 of 3