Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length476 amino acids

Chemical FormulaC2385H3717N607O675S17

DescriptionStandard

        MDFAYRLTFLFSIAAFVGTADAENPGLVVRVTQKGLDYALHEGVIALQQQLSHIQLGEISDTHSLGFFLGKARYKIFGMNLGNVQLPGFQVSPIPNVGLKLSTSGGFFEVNGRWDVRYSFIHEDGTFNIKVGGLGMSVGLNLRNIENGKPTVSVADCSCHIANVEVHMSGTIGWLVKLFHDAVESKIRQELEDKICPEINDIINSKLSSLLQTLPVETNLDHISALDYSLMGPPSVMANWVDVFLKGEFFYRSHRTAPPFAPPAMSLPPEQDHMVYFAVSDYVFNTALLAYQSARALVLTLTDKMIPKEFGVHLNTNLLERVIPAVSKMYPNMPMKLKISAASTPALNITPGGVTLSPIGNFQAYAILPNSSLAPLFLLEVKTNAFAKAAVNSGKIVGTLENGKVEVSLSHSDVGPFSVSEINMAMNLLVPVILPHINDYLKYGFPLPLIEHIQLSDIVIKTYEHYLLFGANVQYQ
    

Molecular Weight52238.79 Da

Isoelectric Point (pI)6.00

Net Charge (pH 7.0)-7.18

Net Charge (pH 7.4) -8.30

Charge Density (pH 7.0) -0.0151

GRAVY Index0.19

Hydrophobic Moment 0.68

Boman Index0.19

Instability Index40.93

Aliphatic Index 103.40

Aromaticity 0.0945

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40465.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0287523 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis (Western clawed frog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria