Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2233H3507N591O618S10

DescriptionStandard

        AHQHGITVLEKELAQLKLPDISGDFRIWHVGKVQYEISRLSLRSFHLPYSRISLVPGVGLQVSISNAFAELDGSWRVKMHFIRDHGSFDLRVENIYIKTHLKLGSDTSGKPTIDTSACSTRISSIRVHFSGKFGWLYNLFHKAIESRFRKILESKVCESVARSVRSELQPYAQTLPVTAKIDAMAGIDYSLVAPPTATAQSLDVDLKGEFFSLAHRSDVPFPPLPLALPPDHDRMVYFGASSYFFNTASFAYHAAGALVFEITNSVIPKGVEFHLNTSTFSAFVPQLEKMYPSMEMKVRLSAPSAPFLYIGPDGLSLKPVVDIQTYVILPNSSLAPLFLLSLVSNVSAVIDVKSGHIVGSLKVGRLKLSLKHSDVGTFQVRMLQSIMNVLASSILLPRLNERLAQGFPLPLPDRIQLSNILVRFHQNFLLLGADVQYQPQ
    

Molecular Weight48840.97 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)9.20

Net Charge (pH 7.4) 8.08

Charge Density (pH 7.0) 0.0209

GRAVY Index0.11

Hydrophobic Moment 0.81

Boman Index0.12

Instability Index38.43

Aliphatic Index 103.23

Aromaticity 0.0955

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 35995.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084777 VERIFIED: NO

Provenance & Taxonomy

OrganismNestor notabilis [other]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria