Peptide Database

Peptide NameWNV(1959-1972)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus

Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Helicase inhibition

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC62H110N28O20

DescriptionStandard

        RRGRIGRNPSQVGD
    

Molecular Weight1567.71 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.56

Charge Density (pH 7.0) 0.1975

GRAVY Index-1.67

Hydrophobic Moment 0.75

Boman Index-0.63

Instability Index66.96

Aliphatic Index 48.57

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 824.14

LogP -12.54

H-bond Donors 30.0

H-bond Acceptors 23.0

Rotatable Bonds 53.0

Heavy Atoms 110.0

Ring Count 1.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0349400 VERIFIED: YES

Provenance & Taxonomy

OrganismWest Nile virus [Virus]

FamilyVirus-derived peptide

Tax ID11082;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Replication inhibitor

TargetWest Nile virus (Replication); Vero

Activity156 μM

MethodHelicase assay

PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/

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