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MYP_109273
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Basic Information
AR-23
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
23 amino acids
C111H190N30O28
Standard
Sequence
AIGSILGALAKGLPTLISWIKNR
Physicochemical Analysis
2392.88 Da
11.17
2.79
2.60
0.1215
0.73
0.55
0.32
15.24
148.70
0.0435
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
928.24
-6.62
33.0
31.0
79.0
169.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0329403 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
113384
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Entry inhibition
Virus pre-treatment
0.39 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperThe Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23. | Chianese A, Zannella C, Monti A, De Filippis A, Doti N, Franci G, Galdiero M. | Int J Mol Sci. 2022 Jan 14;23(2):883. | DOI:10.3390/ijms23020883 | PMID:35055066 PMID35055066 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35055066/
RECORD: Rec_0330755 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human red blood cells
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID12804591;17174009;27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12804591/
RECORD: Rec_0331388 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
113384
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Entry inhibition
Virus pre-treatment
12.5 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperThe Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23. | Chianese A, Zannella C, Monti A, De Filippis A, Doti N, Franci G, Galdiero M. | Int J Mol Sci. 2022 Jan 14;23(2):883. | DOI:10.3390/ijms23020883 | PMID:35055066 PMID35055066 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35055066/
RECORD: Rec_0342339 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus subtilis
3.13 μM
MIC
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID12804591;17174009;27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12804591/
RECORD: Rec_0360916 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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