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MYP_109273
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Basic Information
AR-23
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
23 amino acids
C111H190N30O28
Standard
Sequence
AIGSILGALAKGLPTLISWIKNR
Physicochemical Analysis
2392.88 Da
11.17
2.79
2.60
0.1215
0.73
0.55
0.32
15.24
148.70
0.0435
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
928.24
-6.62
33.0
31.0
79.0
169.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0117616 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
113384
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2 | the cells
25 μM
% inhibition
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperThe Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23. | Chianese A, Zannella C, Monti A, De Filippis A, Doti N, Franci G, Galdiero M. | Int J Mol Sci. 2022 Jan 14;23(2):883. | DOI:10.3390/ijms23020883 | PMID:35055066 PMID35055066 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35055066/
RECORD: Rec_0117804 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic Anticancer
T-lymphoma cells
14 μM
LC50
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID12804591;17174009;27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12804591/
RECORD: Rec_0118585 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
Melittin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Candida albicans
19 μM
MIC
PaperA melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties
RECORD: Rec_0124443 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
melittin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
8.0 μM
HC50
PaperE. Urban et al. / International Journal of Antimicrobial agents 29 (2007) 317-321. Activities of four frog skin-derived antimicrobial peptides (temporin-1DRa, temporin-1Va and the melittin-related peptides AR-23 and RV-23) against anaerobic bacteria Evidence URLhttps://www.uniprot.org/uniprotkb/A7BJK6/entry
RECORD: Rec_0126879 VERIFIED: YES
Provenance & Taxonomy
Rana tagoi [Animal]
melittin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
PaperJ.M. Conlon et al. / Biochemical and Biophysical Research Communications 306 (2003) 496-500. A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties Evidence URLhttps://www.uniprot.org/uniprotkb/A7BJK6/entry
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