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MYP_109268
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Basic Information
C-7 (analog of P18)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
14 amino acids
C91H147N21O15
Standard
Sequence
KWKLFKKIPLAKKF
Physicochemical Analysis
1775.27 Da
10.70
5.75
5.54
0.4110
-0.46
0.45
-0.11
-15.64
90.71
0.2143
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
604.74
1.35
21.0
21.0
62.0
127.0
5.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0261885 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Proteus vulgaris
3.125 μM
MIC
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0277220 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
P18 and analogs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial
Jurkat (blood cancer)
>100 μM
IC50
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs | https://pubmed.ncbi.nlm.nih.gov/12005420/ PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0301310 VERIFIED: YES
Provenance & Taxonomy
Insecta [Animal]
50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0311175 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Staphylococcus aureus KCTC 1621
6.25 μM
MIC
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0388255 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Escherichia coli KCTC 1682
6.25-12.5 μM
MIC
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. PMID12005420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
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