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MYP_109226
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Basic Information
Maximin-H3 (Toads, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C92H165N23O22
Standard
Sequence
ILGPVLGLVGNALGGLIKKI
Physicochemical Analysis
1945.43 Da
10.00
1.76
1.55
0.0879
1.39
0.56
0.55
17.95
190.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
702.56
-2.89
23.0
24.0
66.0
137.0
1.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0285854 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0321780 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Maximin H
161274
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Antimycoplasma
PaperWen-Hui Lee et al. / FEBS Letters 579 (2005) 4443-4448. Maximin 9, a novel free thiol containing antimicrobial peptide with antimycoplasma activity from frog Bombina maxima Evidence URLhttps://www.uniprot.org/uniprotkb/Q4L0B6/entry
RECORD: Rec_0321898 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
161274
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
fungi Candida albicans ATCC 2002
5 μg/mL
MIC
PaperAntimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
RECORD: Rec_0351305 VERIFIED: NO
Provenance & Taxonomy
Bombina maxima [Animal]; Bombina microdeladigitora [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0366226 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Maximin
161274
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
20 μg/mL
MIC
PMID11835991 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11835991/
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