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MYP_109160
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Basic Information
Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G; C-terminal truncated form]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antibiotic activity
Enzyme / Catalytic activity ▸ Hydrolase
Enzyme / Catalytic activity ▸ Protease
Enzyme / Catalytic activity ▸ Protease ▸ Serine protease
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
255 amino acids
C1255H2040N404O354S12
Standard
Sequence
MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL
Physicochemical Analysis
28836.90 Da
11.19
19.99
19.35
0.0784
-0.43
0.80
-0.12
60.87
84.12
0.0627
23950.00
24325.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0049959 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Peptidase S1
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antibiofilm Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Serine protease Chemotactic Cytotoxic Proteolytic Non-hemolytic
Pseudomonas aeruginosa (Gram-negative)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID3304423;2569462;15489334;8194606;3799965;2501794;1861080;7897245;26274980;3390156;2383548;2116408;2117044;2126324;1937776;7842483;7744748;7499346;8920993;9000539;9536127;10702240;11259672;15385470;15210802;15100291;16963625;18586676;18217133;21269460;22275911;22879591;22307629;25944712;29077095;29652924;30804664;32144329;33589665;32995850;8896442;11942800;15741158;32303641;8454293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3304423/
RECORD: Rec_0106607 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Peptidase S1
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antibiofilm Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Serine protease Chemotactic Cytotoxic Proteolytic Non-hemolytic
M. tuberculosis (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID3304423;2569462;15489334;8194606;3799965;2501794;1861080;7897245;26274980;3390156;2383548;2116408;2117044;2126324;1937776;7842483;7744748;7499346;8920993;9000539;9536127;10702240;11259672;15385470;15210802;15100291;16963625;18586676;18217133;21269460;22275911;22879591;22307629;25944712;29077095;29652924;30804664;32144329;33589665;32995850;8896442;11942800;15741158;32303641;8454293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3304423/
RECORD: Rec_0217516 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Peptidase S1
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antibiofilm Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Serine protease Chemotactic Cytotoxic Proteolytic Non-hemolytic
Listeria monocytogenes (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID3304423;2569462;15489334;8194606;3799965;2501794;1861080;7897245;26274980;3390156;2383548;2116408;2117044;2126324;1937776;7842483;7744748;7499346;8920993;9000539;9536127;10702240;11259672;15385470;15210802;15100291;16963625;18586676;18217133;21269460;22275911;22879591;22307629;25944712;29077095;29652924;30804664;32144329;33589665;32995850;8896442;11942800;15741158;32303641;8454293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3304423/
RECORD: Rec_0276885 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Peptidase S1
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antibiofilm Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Serine protease Chemotactic Cytotoxic Proteolytic Non-hemolytic
Staphylococcus aureus (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID3304423;2569462;15489334;8194606;3799965;2501794;1861080;7897245;26274980;3390156;2383548;2116408;2117044;2126324;1937776;7842483;7744748;7499346;8920993;9000539;9536127;10702240;11259672;15385470;15210802;15100291;16963625;18586676;18217133;21269460;22275911;22879591;22307629;25944712;29077095;29652924;30804664;32144329;33589665;32995850;8896442;11942800;15741158;32303641;8454293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3304423/
RECORD: Rec_0289048 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Peptidase S1
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antibiofilm Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Serine protease Chemotactic Cytotoxic Proteolytic Non-hemolytic
N. gonorrhoeae (Gram-negative)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID3304423;2569462;15489334;8194606;3799965;2501794;1861080;7897245;26274980;3390156;2383548;2116408;2117044;2126324;1937776;7842483;7744748;7499346;8920993;9000539;9536127;10702240;11259672;15385470;15210802;15100291;16963625;18586676;18217133;21269460;22275911;22879591;22307629;25944712;29077095;29652924;30804664;32144329;33589665;32995850;8896442;11942800;15741158;32303641;8454293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3304423/
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