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MYP_109085
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Basic Information
Dermaseptin DPh-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C109H184N30O31
Standard
Sequence
GLWSTIKNVGKEAAIAAGKAALGAL
Physicochemical Analysis
2410.81 Da
9.70
1.76
1.55
0.0704
0.58
0.60
0.31
2.09
117.60
0.0400
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
976.42
-9.19
34.0
33.0
81.0
170.0
2.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0125055 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiprotozoal
Micrococcus luteus A270
6 μM
MIC
PMID16844081;16963159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16844081/
RECORD: Rec_0133567 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Refer PubMed ID 16963159 :- Micrococcus luteus
26.5 μM
MIC
PMID16963159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16963159/
RECORD: Rec_0135999 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
Pseudomonas aeruginosa wt MR
6.6 μM
MIC
PaperNovel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).
RECORD: Rec_0146869 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiprotozoal Hemolytic
PMID16844081;16963159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16844081/
RECORD: Rec_0172328 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa azurea [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
0.4 μM
MIC
PaperA.H. Thompson et al. / Peptides 28 (2007) 1331-1343. A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea Evidence URLhttps://www.uniprot.org/uniprotkb/Q1EJP5/entry
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