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MYP_109085
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Basic Information
Dermaseptin DPh-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C109H184N30O31
Standard
Sequence
GLWSTIKNVGKEAAIAAGKAALGAL
Physicochemical Analysis
2410.81 Da
9.70
1.76
1.55
0.0704
0.58
0.60
0.31
2.09
117.60
0.0400
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
976.42
-9.19
34.0
33.0
81.0
170.0
2.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0078176 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiprotozoal
Escherichia coli SBS 363
6 μM
MIC
PMID16844081;16963159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16844081/
RECORD: Rec_0089999 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa azurea [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
0.8 μM
MIC
PaperA.H. Thompson et al. / Peptides 28 (2007) 1331-1343. A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea Evidence URLhttps://www.uniprot.org/uniprotkb/Q1EJP5/entry
RECORD: Rec_0093988 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]; Phyllomedusa hypochondrialis azurea [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli and, Staphylococcus aureus
RECORD: Rec_0097265 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
Staphylococcus aureus ATCC 43300 MRSA
26.5 μM
MIC
PaperNovel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).
RECORD: Rec_0117213 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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