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MYP_109085
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Basic Information
Dermaseptin DPh-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C109H184N30O31
Standard
Sequence
GLWSTIKNVGKEAAIAAGKAALGAL
Physicochemical Analysis
2410.81 Da
9.70
1.76
1.55
0.0704
0.58
0.60
0.31
2.09
117.60
0.0400
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
976.42
-9.19
34.0
33.0
81.0
170.0
2.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013082 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0033762 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiprotozoal
erythrocytes
PMID16844081;16963159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16844081/
RECORD: Rec_0038249 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa azurea [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 12600
0.4 μM
MIC
PMID17553595 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17553595/
RECORD: Rec_0056518 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa azurea [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus ATCC 49732
0.8 μM
MIC
PMID17553595 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17553595/
RECORD: Rec_0077749 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiprotozoal
PMID16844081;16963159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16844081/
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