‹ ›
MYP_109022
← PREVIOUS NEXT → BACK
Basic Information
Hadrurin
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
41 amino acids
C199H333N57O57
Standard
Sequence
GILDTIKSIASKVWNSKTVQDLKRKGINWVANKLGVSPQAA
Physicochemical Analysis
4436.12 Da
10.30
4.76
4.54
0.1160
-0.20
0.63
0.01
28.54
104.63
0.0488
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1879.56
-19.46
65.0
62.0
152.0
313.0
5.0
45.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0022679 VERIFIED: YES
Provenance & Taxonomy
Hoffmannihadrurus aztecus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0025431 VERIFIED: YES
Provenance & Taxonomy
Hadrurus aztecus [Animal]
Hadrurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PaperEur J Biochem. 2000 Aug;267(16):5023-31. | http://www.ncbi.nlm.nih.gov/pubmed/10931184 PMID10931184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10931184/
RECORD: Rec_0050005 VERIFIED: YES
Provenance & Taxonomy
Hadrurus aztecus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Enterobacter cloacae
PaperPubMed PMID: 10931184 PMID10931184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10931184/
RECORD: Rec_0103438 VERIFIED: YES
Provenance & Taxonomy
Hadrurus aztecus [Animal]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
Reported to be the first antimicrobial peptide ever purified from scorpion venom. Host expression:constitutive: The scorpion makes hadrurin as a cytolytic poison for an attack of its prey and as an antimicrobial defense molecule to stop putative invasive microorganisms
Bio-Activity Profile
Antimicrobial
S. thyphi
40 μM
MIC
PaperHadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.
RECORD: Rec_0114538 VERIFIED: YES
Provenance & Taxonomy
Hadrurus aztecus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Klebsiella pneumoniae
PaperPubMed PMID: 10931184 PMID10931184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10931184/
1 2 3 ... 5 NEXT LAST
Showing 5 records on this page · Page 1 of 5