Peptide Database

Peptide NameTenecin-1

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length84 amino acids

Chemical FormulaC403H655N115O113S8

DescriptionStandard

        MKLTIFALVACFFILQIAAFPLEEAATAEEIEQGEHIRVKRVTCDILSVEAKGVKLNDAACAAHCLFRGRSGGYCNGKRVCVCR
    

Molecular Weight9175.73 Da

Isoelectric Point (pI)8.21

Net Charge (pH 7.0)1.62

Net Charge (pH 7.4) 1.18

Charge Density (pH 7.0) 0.0193

GRAVY Index0.36

Hydrophobic Moment 0.64

Boman Index0.10

Instability Index59.71

Aliphatic Index 98.81

Aromaticity 0.0714

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3658.13

LogP -32.65

H-bond Donors 135.0

H-bond Acceptors 125.0

Rotatable Bonds 309.0

Heavy Atoms 639.0

Ring Count 9.0

Amide Bonds 87.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0102054 VERIFIED: YES

Provenance & Taxonomy

OrganismTenebrio molitor [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-positive Cytotoxic Non-hemolytic

TargetGram-positive bacteria