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MYP_108994
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
7 amino acids
C44H61N7O11
Standard
Sequence
YPFVEPI
Physicochemical Analysis
864.00 Da
4.05
-1.24
-1.44
-0.1769
0.50
0.47
0.49
81.23
97.14
0.2857
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
277.87
1.08
8.0
10.0
21.0
62.0
4.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015229 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
beta-Casein-derived
9606
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cell-proliferative Growth-promoting Beta-cell trophic
Promote beta-cell development
PaperThe protective effects of human milk-derived peptides on the pancreatic islet biology | Singh, A. et al. | DOI: 10.1242/bio.049304 Evidence URLhttps://www.uniprot.org/uniprotkb/P05814/entry
RECORD: Rec_0083994 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Casein-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
RECORD: Rec_0105851 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Casomorphin
9606
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Anticancer Cytotoxic Anti-breast cancer Cell-proliferative
decreased breastcancer cell proliferation
Cell proliferation assay
PaperAntiproliferative and receptor binding properties of α- and β-casomorphins in the T47D human breast cancer cell line | Hatzoglou, A. et al. | DOI: 10.1016/0014-2999(96)00339-1 Evidence URLhttps://www.uniprot.org/uniprotkb/P05814/entry
RECORD: Rec_0132266 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
beta-Casein-derived
9606
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid receptor ligand Mucin secretagogue
HT29-MTX cells
Paperβ-Casein(94-123)-derived peptides differently modulate production of mucins in intestinal goblet cells | Plaisancie, P. et al. | DOI: 10.1017/S0022029914000533 Evidence URLhttps://www.uniprot.org/uniprotkb/P05814/entry
RECORD: Rec_0408560 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Endomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-III Inhibitory
Dipeptidyl peptidase III
PaperBarsun M., Jajcanin N., Vukelic B., Spoljaric J., Abramic M.. Human dipeptidyl peptidase III acts as a post-prolinecleaving enzyme on endomorphins. Biological Chemistry, 388, 343-348, 2007.