Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC190H306N56O55S

DescriptionStandard

        RQIKINFQNRRMKNKKGELDELVYLLDGPGYDPIHS
    

Molecular Weight4286.87 Da

Isoelectric Point (pI)9.31

Net Charge (pH 7.0)1.85

Net Charge (pH 7.4) 1.58

Charge Density (pH 7.0) 0.0514

GRAVY Index-1.04

Hydrophobic Moment 0.38

Boman Index-0.25

Instability Index29.77

Aliphatic Index 83.89

Aromaticity 0.0833

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1845.34

LogP -16.28

H-bond Donors 62.0

H-bond Acceptors 59.0

Rotatable Bonds 148.0

Heavy Atoms 302.0

Ring Count 6.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0306997 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 30.6%, E 0.0%, T 50.0%, C 19.4% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Antimicrobial

RECORD: Rec_0403362 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Protease inhibitor Replication inhibitor

TargetHepatitis C virus (Replication); Escherichia coli

Activity0.0236 μM

MethodFRET assay

PaperHigh affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants. | Kugler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J. | J Biol Chem. 2012 | PMID:22965230 PMID22965230 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22965230/