Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length186 amino acids

Chemical FormulaC938H1484N256O252S7

DescriptionStandard

        PMTLPVAHEPMLLLAVTEFVANSAAFTYFTAGALRRNISSNMLPRQFPLQLRTKSMEVFSSQLQERYPDHPMELHLWAHRQPLLSFHPDALHGSLFSSAEAFVVLPNATRVPAFLLDIDANVTGKPTITRNRVGGTVRLTGLVPNPELARGLLVPQVKRLETLLKFGLWLFGVPQANSKCCPVLSP
    

Molecular Weight20603.84 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)5.48

Net Charge (pH 7.4) 5.07

Charge Density (pH 7.0) 0.0295

GRAVY Index0.10

Hydrophobic Moment 0.55

Boman Index0.12

Instability Index45.06

Aliphatic Index 99.09

Aromaticity 0.0806

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7979.89

LogP -91.07

H-bond Donors 274.0

H-bond Acceptors 270.0

Rotatable Bonds 653.0

Heavy Atoms 1453.0

Ring Count 41.0

Amide Bonds 200.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0209535 VERIFIED: NO

Provenance & Taxonomy

OrganismCinclus mexicanus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria