Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2336H3709N629O664S14

DescriptionStandard

        MVWTFVFVLLGSGCRAEGTNAGLKGRITQRGLEYGQQFGLEAVKSLLKKKYIPDLNGSYNIPLLGDVGYSVSRIQIQELQLNESVVSFSEGTGVRLVVSSARVQLHGVWRVKVLFVPDSGSFDLSVSNLSLSTELGVSRDDSGRPQMWSTNCRSSIGRLDVKFHDGVSWLYNLFSGALQAPLRYEVNRQLCPELGKGISDLQRVLKTMHVSAQIDPFAAIDYSLVNKPVIAREHGDMDLKGEFYGVGKHRESPFSPAPFLLPDEGDHMLLLGLSEFSANSAAFVYFTAGALRKNFRDDMIPKRSPIRLNTGSVGLFFPELRKLYPDMPMELHLSARKQPLLTCHPDSLALALFGTAEAFVVLPNATLASAFLLDLDASLAGQLHLDSAKVGGSVALTDFSLSVVRSHVGSVQVKTLETLLKLALRMVALPMANKKLKKGFPLPSIYNLSLVNPHVKINQGFVLVATDVQYKA
    

Molecular Weight51678.16 Da

Isoelectric Point (pI)9.06

Net Charge (pH 7.0)7.46

Net Charge (pH 7.4) 6.53

Charge Density (pH 7.0) 0.0158

GRAVY Index0.07

Hydrophobic Moment 0.80

Boman Index0.10

Instability Index30.29

Aliphatic Index 101.99

Aromaticity 0.0847

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006143 VERIFIED: NO

Provenance & Taxonomy

OrganismGopherus agassizii [Animal]

FamilyBPI

Tax ID38772

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence