Peptide Database

Peptide NameSLAY-screened peptide P4161

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC114H167N33O27

DescriptionStandard

        PPHSPIYQHPSHFAVHRPLLT
    

Molecular Weight2431.75 Da

Isoelectric Point (pI)9.18

Net Charge (pH 7.0)1.31

Net Charge (pH 7.4) 1.05

Charge Density (pH 7.0) 0.0622

GRAVY Index-0.55

Hydrophobic Moment 0.36

Boman Index0.09

Instability Index51.65

Aliphatic Index 74.29

Aromaticity 0.0952

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 896.80

LogP -6.69

H-bond Donors 30.0

H-bond Acceptors 32.0

Rotatable Bonds 66.0

Heavy Atoms 174.0

Ring Count 11.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0080949 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/