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MYP_108661
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Basic Information
Labyrinthopeptin A1
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Standard
20 amino acids
C92H131N23O30S4
Standard
Sequence
SNASVWECCSTGSWVPFTCC
Physicochemical Analysis
2167.42 Da
4.05
-1.58
-1.84
-0.0788
0.38
0.20
0.25
42.24
34.00
0.1500
11000.00
11250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
840.78
-11.04
34.0
33.0
61.0
149.0
6.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006580 VERIFIED: YES
Provenance & Taxonomy
Actinomadura namibiensis [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID20191635 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20191635/
RECORD: Rec_0117428 VERIFIED: YES
Provenance & Taxonomy
Actinomadura namibiensis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0197012 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 10.0%, T 35.0%, C 55.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0238721 VERIFIED: YES
Provenance & Taxonomy
Actinomadura namibiensis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
LabyA1 contains a special amino acid labionin at positions 1, 4, 8, 10, 13, and 19. Labs 1,4 and labs 10, 13 are connected via a carbon-carbon bond, while labs 4, 8 and labs 13, 19 form normal thioether bonds. In addition, a disulfide bond occurs between C9 and C20
Bio-Activity Profile
Antiviral
various strains in different cell lines
0.8-3.3 μM
EC50
PaperThe lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications.
RECORD: Rec_0247311 VERIFIED: YES
Provenance & Taxonomy
Actinomadura namibiensis [Animal]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antiviral Anti-HIV Anti-HSV
HSV(EC50: 0.29
PaperPubMed PMID: 23724015 PMID23724015 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23724015/