Peptide Database

Peptide NameSLAY-screened peptide P4115

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC62H98N22O18S2

DescriptionStandard

        TFRCMLHDRSHT
    

Molecular Weight1503.71 Da

Isoelectric Point (pI)7.97

Net Charge (pH 7.0)0.56

Net Charge (pH 7.4) 0.26

Charge Density (pH 7.0) 0.0470

GRAVY Index-0.84

Hydrophobic Moment 0.16

Boman Index-0.32

Instability Index70.67

Aliphatic Index 32.50

Aromaticity 0.0833

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 662.57

LogP -7.61

H-bond Donors 26.0

H-bond Acceptors 23.0

Rotatable Bonds 48.0

Heavy Atoms 104.0

Ring Count 3.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0025582 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/