‹ ›
MYP_108549
← PREVIOUS NEXT → BACK
Basic Information
UL54(1221-1240)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HCMV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
20 amino acids
C111H173N31O27
Standard
Sequence
LPRRLHLEPAFLPYSVKAHE
Physicochemical Analysis
2373.75 Da
8.60
0.94
0.63
0.0472
-0.37
0.25
-0.03
67.20
102.50
0.1000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
912.09
-4.49
31.0
30.0
72.0
169.0
7.0
19.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0074610 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0122531 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
human cytomegalovirus(HCMV):inhibition of phyical interaction between UL54 and UL44
500 μM
IC50
PaperPubMed PMID: 12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0184796 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCMV
Human cytomegalovirus(HCMV)
500 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of human cytomegalovirus DNA polymerase by C-terminal peptides from the UL54 subunit. | Loregian A, Rigatti R, Murphy M, Schievano E, Palu G, Marsden HS. | J Virol. 2003 Aug;77(15):8336-44. | DOI:10.1128/jvi.77.15.8336-8344.2003 | PMID:12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0304654 VERIFIED: YES
Provenance & Taxonomy
Human betaherpesvirus 5 [Virus]
Virus-derived peptide
10359;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Human cytomegalovirus (Disrupt UL54/UL44 interaction); Sf9
500 μM
ELISA
PaperInhibition of human cytomegalovirus DNA polymerase by C-terminal peptides from the UL54 subunit. | Loregian A, Rigatti R, Murphy M, Schievano E, Palu G, Marsden HS. | J Virol. 2003 | PMID:12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0326408 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 10.0%, T 30.0%, C 60.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/