Peptide Database

Peptide NameBeta-defensin 112

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length113 amino acids

Chemical FormulaC556H876N166O174S10

DescriptionStandard

        MKLLTTICRLKLEKMYSKTNTSSTIFEKARHGTEKISTARSEGHHITFSRWKSCTAIGGRCKNQCDDSEFRISYCARPTTHCCVTECDPTDPNNWIPKDSVGTQEWYPKDSRH
    

Molecular Weight12990.56 Da

Isoelectric Point (pI)8.82

Net Charge (pH 7.0)4.87

Net Charge (pH 7.4) 4.25

Charge Density (pH 7.0) 0.0431

GRAVY Index-0.87

Hydrophobic Moment 0.53

Boman Index-0.21

Instability Index53.76

Aliphatic Index 46.64

Aromaticity 0.0796

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5534.62

LogP -66.62

H-bond Donors 206.0

H-bond Acceptors 194.0

Rotatable Bonds 430.0

Heavy Atoms 906.0

Ring Count 22.0

Amide Bonds 118.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0054276 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

RECORD: Rec_0221848 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyBeta-defensin; Defensin

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Non-hemolytic