Peptide Database

Peptide NameSHP2

Function Ontology

Anticancer

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC73H100N22O16

DescriptionStandard

        FRRKAFSHWYSG
    

Molecular Weight1541.71 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)2.85

Net Charge (pH 7.4) 2.59

Charge Density (pH 7.0) 0.2371

GRAVY Index-1.07

Hydrophobic Moment 0.29

Boman Index-0.23

Instability Index54.50

Aliphatic Index 8.33

Aromaticity 0.3333

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 638.40

LogP -4.85

H-bond Donors 25.0

H-bond Acceptors 20.0

Rotatable Bonds 47.0

Heavy Atoms 111.0

Ring Count 6.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0271256 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermFITC, 5(6)-carboxy fluorescence

C-TermNone

Other ModsStapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling

Bio-Activity Profile

Function

Anticancer

TargetMCF-7

Activity37.21±2.66 μM

MethodIC50

PaperAdak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S. Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors. J Med Chem. 2022 Oct 27;65(20):13866-13884. PMID36240440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36240440/