Peptide Database

Peptide NameVelaglucerase alfa

Function Ontology

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length255 amino acids

Chemical FormulaC1278H1946N334O368S10

DescriptionStandard

        ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEH
    

Molecular Weight28197.79 Da

Isoelectric Point (pI)7.79

Net Charge (pH 7.0)1.28

Net Charge (pH 7.4) 0.64

Charge Density (pH 7.0) 0.0050

GRAVY Index-0.21

Hydrophobic Moment 0.76

Boman Index0.08

Instability Index40.34

Aliphatic Index 75.45

Aromaticity 0.1176

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38765.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0393943 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyEnzyme

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Enzyme replacement

Half-Life11-12 min

PaperPubMed-linked source references: PMID:25501675; PMID:24612151; PMID:24581483; PMID:24411065; PMID:23430813; PMID:20336596; PMID:24630271 PMID25501675;24612151;24581483;24411065;23430813;20336596;24630271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25501675/ PatentUS7138262