Peptide Database

Peptide NameMT-WQ(626-653)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC160H252N40O51S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELIKKSQNQQ
    

Molecular Weight3584.02 Da

Isoelectric Point (pI)5.19

Net Charge (pH 7.0)-1.49

Net Charge (pH 7.4) -1.73

Charge Density (pH 7.0) -0.0532

GRAVY Index-1.71

Hydrophobic Moment 0.69

Boman Index-0.37

Instability Index60.10

Aliphatic Index 55.71

Aromaticity 0.1071

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1551.10

LogP -11.31

H-bond Donors 52.0

H-bond Acceptors 51.0

Rotatable Bonds 130.0

Heavy Atoms 252.0

Ring Count 5.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0095037 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 IIIB:inhibition of virus infection in MT-2 cells

Activity0.0088±0.0004 μM

MethodIC50

RECORD: Rec_0288681 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

Targetinhibition of peptide against cell-cell fusion between H9/HIV-1 IIIB cells and MT-2 cells

Activity0.0148±0.0028 μM

MethodIC50

RECORD: Rec_0297774 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 IIIB | MT-2 cells

Activity0.0088±0.0004 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/

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