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MYP_108513
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Basic Information
MT-WQ(626-653)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
28 amino acids
C160H252N40O51S
Standard
Sequence
MTWEEWDKKIEEYTKKIEELIKKSQNQQ
Physicochemical Analysis
3584.02 Da
5.19
-1.49
-1.73
-0.0532
-1.71
0.69
-0.37
60.10
55.71
0.1071
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1551.10
-11.31
52.0
51.0
130.0
252.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035978 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
inhibition of peptide against cell-cell fusion between H9/HIV-1 IIIB cells and MT-2 cells
0.0148±0.0028 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0055924 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 IIIB
PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0070656 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 BaL
PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0071744 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 Bal | MT-2 cells
0.0067±0.0005 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0088778 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 Bal:inhibition of virus infection in MT-2 cells
0.0067±0.0005 μM
IC50
PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
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