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MYP_108503
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Basic Information
Brevinin-2R
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C114H198N34O33S2
Standard
Sequence
KLKNFAKGVAQSLLNKASCKLSGQC
Physicochemical Analysis
2637.13 Da
9.90
4.74
4.50
0.1894
-0.16
0.60
-0.06
27.08
86.00
0.0400
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1124.87
-13.80
40.0
40.0
95.0
183.0
1.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294314 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus,Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Mouse B-cell lymphoma BJAB
30-40 μg/mL
LD50
PMID30811391;18494941 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30811391/
RECORD: Rec_0315377 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus,Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Leishmania major MRHO/IR/75/ER (promastigote)
40-50 μg/mL
IC50
PMID30811391;18494941 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30811391/
RECORD: Rec_0326606 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus,Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Leishmania major MRHO/IR/75/ER (promastigote)
500 μg/mL
PMID30811391;18494941 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30811391/
RECORD: Rec_0333074 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 36.0%, E 0.0%, T 24.0%, C 40.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0344166 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus,Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Human breast adenocarcinoma MCF-7
10-15 μg/mL
LD50
PMID30811391;18494941 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30811391/
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