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MYP_108503
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Basic Information
Brevinin-2R
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C114H198N34O33S2
Standard
Sequence
KLKNFAKGVAQSLLNKASCKLSGQC
Physicochemical Analysis
2637.13 Da
9.90
4.74
4.50
0.1894
-0.16
0.60
-0.06
27.08
86.00
0.0400
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1124.87
-13.80
40.0
40.0
95.0
183.0
1.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0205186 VERIFIED: YES
Provenance & Taxonomy
Animalia [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID18494941 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18494941/
RECORD: Rec_0248530 VERIFIED: YES
Provenance & Taxonomy
Rana ridibunda [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
19-25
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus aureus, Micrococcus luteus, Bacillus spKR-8104, Escherichia coli, Salmonella Typhimurium, Pseudomonas aeruginosa, K. pneumonidae
PaperBrevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway.
RECORD: Rec_0266544 VERIFIED: YES
Provenance & Taxonomy
Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0277925 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus,Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Jurkat T-cell leukemia
20-25 μg/mL
LD50
PMID30811391;18494941 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30811391/
RECORD: Rec_0292565 VERIFIED: YES
Provenance & Taxonomy
Animalia [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID18494941 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18494941/
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