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MYP_108503
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Basic Information
Brevinin-2R
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C114H198N34O33S2
Standard
Sequence
KLKNFAKGVAQSLLNKASCKLSGQC
Physicochemical Analysis
2637.13 Da
9.90
4.74
4.50
0.1894
-0.16
0.60
-0.06
27.08
86.00
0.0400
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1124.87
-13.80
40.0
40.0
95.0
183.0
1.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015486 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
19-25
Bio-Activity Profile
Anticancer
PaperS. Ghavami et al. / Journal of Cellular and Molecular Medicine 12 (2008) 1005-1022. Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway Evidence URLhttps://www.uniprot.org/uniprotkb/P85095/entry
RECORD: Rec_0050299 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus,Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
500 μg/mL
Hemolysis
PMID30811391;18494941 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30811391/
RECORD: Rec_0108213 VERIFIED: NO
Provenance & Taxonomy
Marsh frog [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
19-25
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0127724 VERIFIED: NO
Provenance & Taxonomy
Rana ridibunda [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
RECORD: Rec_0157193 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus,Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Escherichia coli ATCC 25922
6.25 μg/mL
MBC
PMID30811391;18494941 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30811391/
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