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MYP_108473
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Basic Information
Tilapia piscidin 3, TP3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
23 amino acids
C121H182N36O26
Standard
Sequence
FIHHIIGGLFSVGKHIHSLIHGH
Physicochemical Analysis
2556.97 Da
8.79
1.28
0.77
0.0557
0.59
0.57
0.44
57.34
131.30
0.0870
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
942.08
-5.04
33.0
33.0
82.0
183.0
8.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0058185 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 30012343 PMID30012343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30012343/
RECORD: Rec_0076137 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
128 μg/mL
MIC
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0102285 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Toxic Hemolytic Anti-Gram-positive Cytotoxic Anti-Gram-negative Wound healing
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0104178 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Piscidin
8128
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-MDV Replication inhibition
Foot-and-Mouth Disease virus(FMDV) | BHK-21 cells
2.5±0.2 μg/mL
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperGrouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro. | Huang HN, Pan CY, Chen JY. | Peptides. 2018 Aug;106:91-95. | DOI:10.1016/j.peptides.2018.07.003 | PMID:30012343 PMID30012343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30012343/
RECORD: Rec_0124668 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S. agalactiae BCRC 10787
0.61 μg/mL
MIC
PMID23226256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226256/
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