Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2577H3999N639O741S18

DescriptionStandard

        MHTKAVQVLWGCFFLWDLYVSSAQTVYPGIKARVTQRALDYGVLAGMEMIEHMVKEKNIPDLEGSESLEFLKVDYVDYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEIKSPLFEDAGGADLFLSGVYFTGIVVLARNDFGHPILKLQRCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIMSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYMELNLKGVFYPLDNLTDPPFLPVPFVLPERHDSMLYVGISEFFFKSASFAYFTSGAFNVTLSLKEISSHLVQNSQGLGNVLSRIAEIYILSQPFMVRVMATEPPVISLQPGNFTLDIPASMVLLAQTENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESNRSNIEVLRFENILSSLLHFGILPLANAKLQQGIPLPNPHKISFVNSDIEVFEGFLLISTDLKYETSLKQQLSFHGWEGLNLISGQWRGKPVA
    

Molecular Weight56365.32 Da

Isoelectric Point (pI)5.10

Net Charge (pH 7.0)-16.51

Net Charge (pH 7.4) -17.46

Charge Density (pH 7.0) -0.0326

GRAVY Index0.21

Hydrophobic Moment 0.68

Boman Index0.19

Instability Index37.37

Aliphatic Index 105.15

Aromaticity 0.1045

Extinction Coeff. Reduced 51340.00

Extinction Coeff. Oxidized 51590.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0045879 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinus ursinus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence