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MYP_108298
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Basic Information
Esculentin-1GRa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
46 amino acids
C219H366N60O58S3
Standard
Sequence
GLFSKFAGKGIKNLIFKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC
Physicochemical Analysis
4863.81 Da
9.63
4.83
4.53
0.1049
0.19
0.73
0.13
1.21
97.39
0.0652
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1904.31
-15.54
68.0
67.0
174.0
340.0
4.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0120746 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0123549 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
50 μM
MIC
PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0260652 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
6 μM
MIC
PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0267698 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
12.5 μM
MIC
PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0287804 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Toxic Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
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