Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length276 amino acids

Chemical FormulaC1376H2190N382O390S8

DescriptionStandard

        MMARLYCVVVTLLLLAEVSGFEEGATNPGVVARITRKGLAYARQLGVAILKKELSTIKLPDFSGSFKVSWIKTVSYDFYRLTIHRFELRNSDLRLRPRQGVRASLSNNYMFVSGNWKVKKAFVTLDGTFDVNVDGISISVSLNLGKDQSGRPTASVAHCRNSIGHISVDISGQLSWILNLLHKRIENNFKNILEQKIREMVRKSTTSHLEPYLRTPPGLEAPSFLWVPSDAMTPVTPRPMTTIISRAPGELSPWSTSPSHGAGYGVTTSLGGLFWS
    

Molecular Weight30580.95 Da

Isoelectric Point (pI)9.96

Net Charge (pH 7.0)13.02

Net Charge (pH 7.4) 12.42

Charge Density (pH 7.0) 0.0472

GRAVY Index-0.07

Hydrophobic Moment 0.75

Boman Index0.06

Instability Index33.75

Aliphatic Index 93.55

Aromaticity 0.0870

Extinction Coeff. Reduced 43430.00

Extinction Coeff. Oxidized 43555.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0089930 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinus ursinus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence