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MYP_108230
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Basic Information
Mastoparan C
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C72H134N18O16
Standard
Sequence
LNLKALLAVAKKIL
Physicochemical Analysis
1507.95 Da
10.30
2.76
2.55
0.1969
1.28
0.58
0.31
10.91
209.29
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
562.77
-1.04
19.0
19.0
54.0
106.0
0.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0094898 VERIFIED: YES
Provenance & Taxonomy
Vespa crabro [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Antifungal Cytotoxic
Cytotoxicity:Human microvascular endothelial cells HMEC-1
57.15 μM
IC50
PaperNewly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. Eur J Pharm Sci. 2021 Mar 1;158:105665. doi: 10.1016/j.ejps.2020.105665. PMID: 33285267 PMID33285267;29904274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33285267/
RECORD: Rec_0109906 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Vespa crabro [Synthetic]
Mastoparan
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
cancer cells H157, MBD-MB-435S, PC-3, U251-MG, and MCF-7
6-25 μM
IC50
PaperEvaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering
RECORD: Rec_0117947 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Vespa crabro [Synthetic]
Mastoparan
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Listeria monocytogenes ATCC 15313
8 μM
MIC
PaperEvaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering
RECORD: Rec_0117960 VERIFIED: YES
Provenance & Taxonomy
Vespa crabro [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Antifungal
Pseudomonas aeruginosa ATCC 9027(4.5 mM KCl
8 μM
MIC
PaperNewly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. Eur J Pharm Sci. 2021 Mar 1;158:105665. doi: 10.1016/j.ejps.2020.105665. PMID: 33285267 PMID33285267;29904274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33285267/
RECORD: Rec_0127233 VERIFIED: YES
Provenance & Taxonomy
Vespa crabro [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Antifungal Hemolytic
PaperNewly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. Eur J Pharm Sci. 2021 Mar 1;158:105665. doi: 10.1016/j.ejps.2020.105665. PMID: 33285267 PMID33285267;29904274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33285267/
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