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MYP_108230
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Basic Information
Mastoparan C
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C72H134N18O16
Standard
Sequence
LNLKALLAVAKKIL
Physicochemical Analysis
1507.95 Da
10.30
2.76
2.55
0.1969
1.28
0.58
0.31
10.91
209.29
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
562.77
-1.04
19.0
19.0
54.0
106.0
0.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037572 VERIFIED: YES
Provenance & Taxonomy
Vespa crabro [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Antifungal Cytotoxic
Human embryonic kidney HEK293T cells
16 μM
IC50
PaperNewly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. Eur J Pharm Sci. 2021 Mar 1;158:105665. doi: 10.1016/j.ejps.2020.105665. PMID: 33285267 PMID33285267;29904274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33285267/
RECORD: Rec_0039220 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Vespa crabro [Synthetic]
Mastoparan
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Pseudomonas aeruginosa
8-64 μM
MIC
PaperEvaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering
RECORD: Rec_0043022 VERIFIED: YES
Provenance & Taxonomy
Vespa crabro [Animal]
Mastoparan
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
PMID29904274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29904274/
RECORD: Rec_0043080 VERIFIED: YES
Provenance & Taxonomy
Vespa crabro [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Antifungal Hemolytic
mouse erythrocytes
PaperNewly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. Eur J Pharm Sci. 2021 Mar 1;158:105665. doi: 10.1016/j.ejps.2020.105665. PMID: 33285267 PMID33285267;29904274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33285267/
RECORD: Rec_0043842 VERIFIED: YES
Provenance & Taxonomy
Vespa crabro [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Antifungal
Enterococcus faecalis NCTC 12697
8 μM
MIC
PaperNewly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. Eur J Pharm Sci. 2021 Mar 1;158:105665. doi: 10.1016/j.ejps.2020.105665. PMID: 33285267 PMID33285267;29904274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33285267/
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