Peptide Database

Peptide NameMastoparan C

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Hormonal / Endocrine ▸ Hormone peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC72H134N18O16

DescriptionStandard

        LNLKALLAVAKKIL
    

Molecular Weight1507.95 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.1969

GRAVY Index1.28

Hydrophobic Moment 0.58

Boman Index0.31

Instability Index10.91

Aliphatic Index 209.29

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 562.77

LogP -1.04

H-bond Donors 19.0

H-bond Acceptors 19.0

Rotatable Bonds 54.0

Heavy Atoms 106.0

Ring Count 0.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0418295 VERIFIED: YES

Provenance & Taxonomy

OrganismVespa crabro [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Antifungal Cytotoxic

TargetHuman embryonic kidney HEK293T cells

PaperNewly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. Eur J Pharm Sci. 2021 Mar 1;158:105665. doi: 10.1016/j.ejps.2020.105665. PMID: 33285267 PMID33285267;29904274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33285267/

RECORD: Rec_0426198 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct based on Vespa crabro [Synthetic]

FamilyMastoparan

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anticancer

TargetEnterococcus faecalis

Activity4-8 μM

MethodMIC

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